Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury

Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury

Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems – glutathione (GSH) and thioredoxin (Trx) systems – are likely targets for mercurials. Hg exposure results in GSH depletion...

Full description

Bibliographic Details
Main Authors: Vasco Branco, Lucia Coppo, Susana Solá, Jun Lu, Cecília M.P. Rodrigues, Arne Holmgren, Cristina Carvalho
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Redox Biology
Subjects:
Mercury
Thioredoxin
Glutathione
Glutaredoxin
ASK- 1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717303099

Internet

http://www.sciencedirect.com/science/article/pii/S2213231717303099

Similar Items