Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

Myeloid cells are able to utilize a variety of monosaccharides from our diet, including fructose. Here the authors show that when monocytes are reliant on fructose as a carbon energy source they are reprogrammed towards oxidative metabolism, glutamine anaplerosis and a pro-inflammatory phenotype owi...

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Bibliographic Details
Main Authors: Nicholas Jones, Julianna Blagih, Fabio Zani, April Rees, David G. Hill, Benjamin J. Jenkins, Caroline J. Bull, Diana Moreira, Azari I. M. Bantan, James G. Cronin, Daniele Avancini, Gareth W. Jones, David K. Finlay, Karen H. Vousden, Emma E. Vincent, Catherine A. Thornton
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21461-4

Internet

https://doi.org/10.1038/s41467-021-21461-4

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