Oxaliplatin-Induced Senescence in Colorectal Cancer Cells Depends on p14<sup>ARF</sup>-Mediated Sustained p53 Activation

Oxaliplatin-Induced Senescence in Colorectal Cancer Cells Depends on p14<sup>ARF</sup>-Mediated Sustained p53 Activation

Senescence is an important consequence of cytostatic drug-based tumor therapy. Here we analyzed to which degree the anticancer drug oxaliplatin induces cell death, cell cycle arrest, and senescence in colorectal cancer (CRC) cells and elucidated the role of p53. Oxaliplatin treatment resulted in the...

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Bibliographic Details
Main Authors: Maja T. Tomicic, Franziska Krämer, Alexandra Nguyen, Christian Schwarzenbach, Markus Christmann
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
oxaliplatin
cellular senescence
tumor suppressor p53
p14<sup>ARF</sup>
colorectal cancer
Online Access:https://www.mdpi.com/2072-6694/13/9/2019

Internet

https://www.mdpi.com/2072-6694/13/9/2019

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