Case Report: A Rare Truncating Variant of the CFHR5 Gene in IgA Nephropathy

Case Report: A Rare Truncating Variant of the CFHR5 Gene in IgA Nephropathy

IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Despite appropriate therapy, 20–40% of affected-patients evolve toward end-stage kidney disease (ESKD). Mesangial IgA deposits are the hallmark of IgAN, and complement deposition (C3) seems to differentiate latent IgA me...

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Bibliographic Details
Main Authors: Gabriella Guzzo, Salima Sadallah, Heidi Fodstad, Jean-Pierre Venetz, Samuel Rotman, Daniel Teta, Thierry Gauthier, Giuseppe Pantaleo, Andrea Superti-Furga, Manuel Pascual
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Genetics
Subjects:
IgA nephropathy
complement
CFHR5
CFH
eculizumab
atypical hemolytic uremic syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.529236/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.529236/full

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