The MET oncogene as a therapeutical target in cancer invasive growth

The MET oncogene as a therapeutical target in cancer invasive growth

The MET proto-oncogene, encoding the tyrosine kinase receptor for Hepatocyte Growth Factor (HGF) regulates invasive growth, a genetic program that associates control of cell proliferation with invasion of the extracellular matrix and protection from apoptosis. Physiologically, invasive growth takes...

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Bibliographic Details
Main Authors: Paolo eLuraghi, Florian eSchelter, Achim eKrüger, Carla eBoccaccio
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Pharmacology
Subjects:
metastasis
antibody
targeted therapy
microenvironment
invasion
Proteases
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00164/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00164/full

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