Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies.

Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies.

Aggregation of α-synuclein (α-syn) has been implicated in multiple neurodegenerative disorders including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA), collectively grouped as synucleinopathies. Recently, recombinant antibody fragments (Fab, scFvs a...

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Bibliographic Details
Main Authors: Vijay Gupta, Indulekha P Sudhakaran, Zeyaul Islam, Nishant N Vaikath, Issam Hmila, Tamas Lukacsovich, Prasanna R Kolatkar, Omar M A El-Agnaf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0241773

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https://doi.org/10.1371/journal.pone.0241773

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