Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response

Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response

Abstract Background Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid derivative, which has been demonstrated to have neuroprotective effects in different neurological disease models. However, the effect and underlying mechanism of TUDCA on spinal cord injury (SCI) have not been fully elu...

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Bibliographic Details
Main Authors: Yonghui Hou, Jiyao Luan, Taida Huang, Tiancheng Deng, Xing Li, Zhifeng Xiao, Jiheng Zhan, Dan Luo, Yu Hou, Liangliang Xu, Dingkun Lin
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Neuroinflammation
Subjects:
Tauroursodeoxycholic acid
Spinal cord injury
Oxidative stress
Inflammation
Online Access:https://doi.org/10.1186/s12974-021-02248-2

Internet

https://doi.org/10.1186/s12974-021-02248-2

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