TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells.

TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells.

CD74 is a multifunctional protein and a receptor for Macrophage Migration Inhibitory Factor (MIF) and MIF-2 / D-dopachrome tautomerase (DDT) cytokines, upregulated in diabetic kidney disease. However, the drivers of CD74 expression and DDT function in kidney cells are poorly characterized. TWEAK is...

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Bibliographic Details
Main Authors: Lara Valiño-Rivas, Leticia Cuarental, Osvaldo Grana, Richard Bucala, Lin Leng, Ana Sanz, Gonzalo Gomez, Alberto Ortiz, Maria Dolores Sanchez-Niño
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6010292?pdf=render

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http://europepmc.org/articles/PMC6010292?pdf=render

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