Cardioprotective effect of combination therapy by mild hypothermia and local or remote ischemic preconditioning in isolated rat hearts

Abstract A multitargeted strategy to treat the consequences of ischemia and reperfusion (IR) injury in acute myocardial infarction may add cardioprotection beyond reperfusion therapy alone. We investigated the cardioprotective effect of mild hypothermia combined with local ischemic preconditioning (...

Full description

Bibliographic Details
Main Authors: Marie V. Hjortbak, Nichlas R. Jespersen, Rebekka V. Jensen, Thomas R. Lassen, Johanne Hjort, Jonas A. Povlsen, Nicolaj B. Støttrup, Jakob Hansen, Derek J. Hausenloy, Hans Erik Bøtker
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79449-x