Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach

Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach

It is well established that transcriptional silencing of critical tumor-suppressor genes by DNA methylation is a fundamental component in the initiation of breast cancer. However, the involvement of microRNAs (miRNAs) in restoring abnormal DNA methylation patterns in breast cancer is not well unders...

Full description

Bibliographic Details
Main Authors: Athena Starlard-Davenport, Kristi Kutanzi, Volodymyr Tryndyak, Beverly Word, Beverly Lyn-Cook
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Journal of Carcinogenesis
Subjects:
Breast cancer
DNA methylation
DNA methyltransferase1
DNA methyltransferases 3A
DNA methyltransferases 3B
microRNA-29b
Online Access:http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=15;epage=15;aulast=Starlard-Davenport

Internet

http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=15;epage=15;aulast=Starlard-Davenport

Similar Items