Identification of genetic variants or genes that are associated with Homoharringtonine (HHT) response through a genome-wide association study in human lymphoblastoid cell lines (LCLs)

Identification of genetic variants or genes that are associated with Homoharringtonine (HHT) response through a genome-wide association study in human lymphoblastoid cell lines (LCLs)

Homoharringtonine (HHT) has been widely used in China to treat patients with acute and chronic myeloid leukemia for decades. Since response to HHT varies among patients, our study aimed to identify biomarkers that might influence the response to HHT using a panel of various human lymphoblastoid cel...

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Bibliographic Details
Main Authors: Liewei eWang, Yin eTong, Nifang eNiu, Gregory eJenkins, Liang eLi, Krishna Rani Kalari
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Genetics
Subjects:
Genome-Wide Association Study
Leukemia
biomarkers
Homoharringtonine (HHT)
lymphoblastoid cell line system
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00465/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00465/full

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