Decreased production of TNF-alpha by lymph node cells indicates experimental autoimmune encephalomyelitis remission in Lewis rats

Decreased production of TNF-alpha by lymph node cells indicates experimental autoimmune encephalomyelitis remission in Lewis rats

Experimental autoimmune encephalomyelitis (EAE) is mediated by CD4+ Th1 cells that mainly secrete IFN-γ and TNF-α, important cytokines in the pathophysiology of the disease. Spontaneous remission is, in part, attributed to the down regulation of IFN-γ and TNF-α by...

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Bibliographic Details
Main Authors: Juliana Seger, Sofia Fernanda Gonçalves Zorzella-Pezavento, Ana Cláudia Pelizon, Douglas Rodrigues Martins, Alexandre Domingues, Alexandrina Sartori
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2010-05-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
experimental autoimmune encephalomyelitis
tumor necrosis factor
alpha
rats inbred Lew
biomarkers
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000300004

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000300004

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