Niemann-Pick Disease Type C Yields Possible Clue for Why Cerebellar Neurons Do Not Form Neurofibrillary Tangles

Niemann-Pick Disease Type C Yields Possible Clue for Why Cerebellar Neurons Do Not Form Neurofibrillary Tangles

It is unknown why cerebellar neurons resist neurofibrillary tangle (NFT) formation. In Niemann-Pick disease Type C (NPC), NFT-mediated neurodegeneration occurs throughout brain, but the cerebellum degenerates conspicuously without NFT. To understand why, we have studied markers of NFT pathogenesis i...

Full description

Bibliographic Details
Main Authors:	Bitao Bu, Hans Klunemann, Kinuko Suzuki, Jin Li, Thomas Bird, Lee-Way Jin, Inez Vincent
Format:	Article
Language:	English
Published:	Elsevier 2002-11-01
Series:	Neurobiology of Disease
Subjects:	neurofibrillary tangle neurodegeneration Niemann-Pick disease type C Alzheimer's disease cerebellum Purkinje neurons
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996102905516

Similar Items

Filipin-Darstellung des Cholesterins der Tangle-tragenden Neurone in Gehirnen von Patienten mit Alzheimer- und Niemann-Pick-Typ C-Krankheit
by: Distl, Roland
Published: (2003)

In vivo quantification of neurofibrillary tangles with [18F]MK-6240
by: Tharick A. Pascoal, et al.
Published: (2018-07-01)

Identification of Novel Pathways Associated with Patterned Cerebellar Purkinje Neuron Degeneration in Niemann-Pick Disease, Type C1
by: Kyle B. Martin, et al.
Published: (2019-12-01)

Altered Regulation of KIAA0566, and Katanin Signaling Expression in the Locus Coeruleus With Neurofibrillary Tangle Pathology
by: Pol Andrés-Benito, et al.
Published: (2018-05-01)

Lhermitte-Duclos disease with neurofibrillary tangles in heterotopic cerebral grey matter
by: Daniel Rusiecki, et al.
Published: (2016-06-01)

Complement is dispensable for neurodegeneration in Niemann-Pick disease type C
by: Lopez Manuel E, et al.
Published: (2012-09-01)

Anesthetic consideration of Niemann-Pick Disease type C
by: Masoud Nashibi, et al.
Published: (2016-03-01)

Fluctuations in neurofibrillary tangle density in Alzheimer’s disease revealed by Fourier (spectral) analysis
by: Richard Armstrong
Published: (2021-01-01)

Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation
by: Patrick Reilly, et al.
Published: (2017-10-01)

A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain
by: Patrick C. Reid, et al.
Published: (2004-03-01)

Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition
by: David Baglietto-Vargas, et al.
Published: (2014-02-01)

Priapism associated with Niemann-Pick disease in a 15-year-old boy
by: M V Krishna Shetty, et al.
Published: (2011-01-01)

Vitamin E therapy prevents the accumulation of congophilic amyloid plaques and neurofibrillary tangles in the hippocampus in a rat model of Alzheimer’s disease
by: Mehrdad Jahanshahi, et al.
Published: (2020-01-01)

Loss of amyloid precursor protein in a mouse model of Niemann–Pick type C disease exacerbates its phenotype and disrupts tau homeostasis
by: Ana Nunes, et al.
Published: (2011-06-01)

Altered vitamin E status in Niemann-Pick type C disease
by: L. Ulatowski, et al.
Published: (2011-07-01)

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain
by: Motaz M. Fadul, et al.
Published: (2020-01-01)

Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases
by: Mark L. Schultz, et al.
Published: (2019-11-01)

Bone marrow involvement of a patient with Niemann-Pick disease concomitant with Kartagener’s syndrome: Report of a rare case
by: Muzaffer Keklik, et al.
Published: (2014-08-01)

Histogenesis and Histomorphometric Study of Human Foetal Cerebellar Cortex
by: Divya C, et al.
Published: (2020-05-01)

Single Cell Transcriptome Analysis of Niemann–Pick Disease, Type C1 Cerebella
by: Antony Cougnoux, et al.
Published: (2020-07-01)

Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann–Pick disease type C1 mice
by: Ian M. Williams, et al.
Published: (2014-07-01)

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments
by: William S. Garver, et al.
Published: (2000-05-01)

Role of Diffusion Tensor Imaging in Prognostication and Treatment Monitoring in Niemann-Pick Disease Type C1
by: Meghann W. Lau, et al.
Published: (2016-09-01)

Niemann Peak Disease Type A in Necropsy of the Liver of a Four-Month-Old Female with Fe-ver and Pancytopenia
by: Amer Yazdanparast, et al.
Published: (2021-05-01)

Complex N-Linked Glycosylation: A Potential Modifier of Niemann–Pick Disease, Type C1 Pathology
by: Abebe, D., et al.
Published: (2022)

Dental Treatment of Two Children with Niemann Pick Disease Type B Under General Anesthesia: Case Reports
by: Mustafa Sarp KAYA, et al.
Published: (2019-01-01)

Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology
by: Stephen D. Ginsberg, et al.
Published: (2019-12-01)

Niemann-Pick disease type B: HRCT assessment of pulmonary involvement
by: Heloisa Maria Pereira Freitas, et al.

Miglustat therapy in the French cohort of paediatric patients with Niemann-Pick disease type C
by: Héron Bénédicte, et al.
Published: (2012-06-01)

Miglustat in Niemann-Pick disease type C patients: a review
by: Mercè Pineda, et al.
Published: (2018-08-01)

Niemann-Pick disease type C with kidney involvement
by: Aanand A. Patel, et al.
Published: (2021-03-01)

Niemann–Pick Disease Type C Associated with Fuchs Heterochromic Iridocyclitis
by: Farzan Kianersi, et al.
Published: (2017-01-01)

Compound heterozygous Niemann-Pick Type C disease in the neonatal period
by: Deniz Anuk-ince, et al.
Published: (2021-05-01)

Niemann-Pick disease type B. Study of 3 cases and literature revision
by: Jorge Zarco-Román, et al.
Published: (2014-07-01)

A Case Series on Genotype and Outcome of Liver Transplantation in Children with Niemann-Pick Disease Type C
by: Line Modin, et al.
Published: (2021-09-01)

Adult Niemann-Pick disease type B with myositis ossificans: a case report
by: Russka Shumnalieva, et al.
Published: (2016-07-01)

Recommendations for patient screening in ultra-rare inherited metabolic diseases: what have we learned from Niemann-Pick disease type C?
by: María-Jesús Sobrido, et al.
Published: (2019-01-01)

Clinical observations of late infantile and juvenile forms of Niemann – Pick disease type C
by: Irina F. Fedoseeva, et al.
Published: (2017-10-01)

Niemann-Pick Disease Type C Misdiagnosed as Cerebral Palsy: A Case Report
by: Eun Jae Ko, et al.
Published: (2019-10-01)

Effect of dimethylsulfoxide on sphingomyelinase activity and cholesterol metabolism in Niemann-Pick type C fibroblasts
by: F.B. Scalco, et al.
Published: (1999-01-01)