Niemann-Pick Disease Type C Yields Possible Clue for Why Cerebellar Neurons Do Not Form Neurofibrillary Tangles

Niemann-Pick Disease Type C Yields Possible Clue for Why Cerebellar Neurons Do Not Form Neurofibrillary Tangles

It is unknown why cerebellar neurons resist neurofibrillary tangle (NFT) formation. In Niemann-Pick disease Type C (NPC), NFT-mediated neurodegeneration occurs throughout brain, but the cerebellum degenerates conspicuously without NFT. To understand why, we have studied markers of NFT pathogenesis i...

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Bibliographic Details
Main Authors: Bitao Bu, Hans Klunemann, Kinuko Suzuki, Jin Li, Thomas Bird, Lee-Way Jin, Inez Vincent
Format: Article
Language:English
Published: Elsevier 2002-11-01
Series:Neurobiology of Disease
Subjects:
neurofibrillary tangle
neurodegeneration
Niemann-Pick disease type C
Alzheimer's disease
cerebellum
Purkinje neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905516

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http://www.sciencedirect.com/science/article/pii/S0969996102905516

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