Determining the Depth of Injury in Bioengineered Tissue Models of Cornea and Conjunctiva for the Prediction of All Three Ocular GHS Categories.

Determining the Depth of Injury in Bioengineered Tissue Models of Cornea and Conjunctiva for the Prediction of All Three Ocular GHS Categories.

The depth of injury (DOI) is a mechanistic correlate to the ocular irritation response. Attempts to quantitatively determine the DOI in alternative tests have been limited to ex vivo animal eyes by fluorescent staining for biomarkers of cell death and viability in histological cross sections. It was...

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Bibliographic Details
Main Authors: Michaela Zorn-Kruppa, Pia Houdek, Ewa Wladykowski, Maria Engelke, Melinda Bartok, Karsten R Mewes, Ingrid Moll, Johanna M Brandner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4262406?pdf=render

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http://europepmc.org/articles/PMC4262406?pdf=render

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