Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects

Abstract [11C]K-2, a radiotracer exhibiting high affinity and selectivity for α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs), is suitable for the quantification of AMPARs in living human brains and potentially useful in the identification of epileptogenic foci in patients....

Full description

Bibliographic Details
Main Authors: Mai Hatano, Tomoyuki Miyazaki, Yoshinobu Ishiwata, Waki Nakajima, Tetsu Arisawa, Yoko Kuroki, Ayako Kobayashi, Yuuki Takada, Matsuyoshi Ogawa, Kazunori Kawamura, Ming-Rong Zhang, Makoto Higuchi, Masataka Taguri, Yasuyuki Kimura, Takuya Takahashi
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81002-3