Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters
It is widely accepted that the conversion of the soluble, nontoxic amyloid β-protein (Aβ) monomer to aggregated toxic Aβ rich in β-sheet structures is central to the development of Alzheimer’s disease. However, the mechanism of the abnormal aggregation of Aβ in vivo is not well understood. Accumulat...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2011-01-01
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| Series: | International Journal of Alzheimer's Disease |
| Online Access: | http://dx.doi.org/10.4061/2011/956104 |