Functional Characterization of ABCC Proteins from Trypanosoma cruzi and Their Involvement with Thiol Transport

Functional Characterization of ABCC Proteins from Trypanosoma cruzi and Their Involvement with Thiol Transport

Chagas disease is a neglected disease caused by the protozoan Trypanosoma cruzi and affects 8 million people worldwide. The main chemotherapy is based on benznidazole. The efficacy in the treatment depends on factors such as the parasite strain, which may present different sensitivity to treatment....

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Bibliographic Details
Main Authors: Kelli Monteiro da Costa, Raphael C. Valente, Eduardo J. Salustiano, Luciana B. Gentile, Leonardo Freire-de-Lima, Lucia Mendonça-Previato, José O. Previato
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Microbiology
Subjects:
ABC transporters
Trypanosoma cruzi
multidrug resistance phenotype
multidrug resistance protein
P-glycoprotein
thiol transporter
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00205/full

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http://journal.frontiersin.org/article/10.3389/fmicb.2018.00205/full

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