CuO nanoparticles induce cytotoxicity and apoptosis in human K562 cancer cell line via mitochondrial pathway, through reactive oxygen species and P53

CuO nanoparticles induce cytotoxicity and apoptosis in human K562 cancer cell line via mitochondrial pathway, through reactive oxygen species and P53

Objective(s): This study focused on determining cytotoxic effects of copper oxide nanoparticles (CuO NPs) on chronic myeloid leukemia (CML) K562 cell line in a cell-specific manner and its possible mechanism of cell death. We investigated the cytotoxicity of CuO NPs against K562 cell line (cancerous...

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Bibliographic Details
Main Authors: Maryam Shafagh, Fatemeh Rahmani, Norouz Delirezh
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2015-10-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Apoptosis
Bax/Bcl-2
CuO nanoparticles
K562
P53
ROS
Cancer
Online Access:http://ijbms.mums.ac.ir/pdf_5463_1462354a32e832a2fca809b1ca17b027.html

Internet

http://ijbms.mums.ac.ir/pdf_5463_1462354a32e832a2fca809b1ca17b027.html

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