Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats

Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats

Objectives: Mitochondrial oxidative stress is involved in the pathogenesis of diabetic kidney disease. The objective of our study is to identify the mechanisms of renal mitochondrial oxidative stress, focusing on Sirt3, which is nicotinamide adenine dinucleotide (NAD+; oxidized NAD)-dependent deacet...

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Bibliographic Details
Main Authors: Yoshio Ogura, Munehiro Kitada, Itaru Monno, Keizo Kanasaki, Ai Watanabe, Daisuke Koya
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Redox Report
Subjects:
Diabetic kidney disease
Zucker diabetic fatty rat
Sirt3
mitochondrial oxidative stress
isocitrate dehydrogenase2
superoxide dismutase2
CD38
NAD+/NADH ratio
Online Access:http://dx.doi.org/10.1080/13510002.2018.1487174

Internet

http://dx.doi.org/10.1080/13510002.2018.1487174

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