Chloroquine augments TRAIL-induced apoptosis and induces G2/M phase arrest in human pancreatic cancer cells.

Chloroquine augments TRAIL-induced apoptosis and induces G2/M phase arrest in human pancreatic cancer cells.

Autophagy contributes to the treatment-resistance of many types of cancers, and chloroquine (CQ) inhibits autophagy. The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) kills cancer cells but is minimally cytotoxic to normal cells. However, because the therapeutic efficacy of T...

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Bibliographic Details
Main Authors: Hiroyuki Monma, Yuichi Iida, Tamami Moritani, Tamio Okimoto, Ryosuke Tanino, Yoshitsugu Tajima, Mamoru Harada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5841811?pdf=render

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http://europepmc.org/articles/PMC5841811?pdf=render

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