Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

<p>Abstract</p> <p>Background</p> <p>Survivin is a dual functioning protein. It inhibits the apoptosis of cancer cells by inhibiting caspases, and also promotes cancer cell growth by stabilizing microtubules during mitosis. Since the molecular chaperone Hsp90 binds and...

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Bibliographic Details
Main Authors: Lyu Kevin W, Kanwar Jagat R, Cheng Li-Ting, Chen Huang-Hui, Cheung Chun Hei Antonio, Chang Jang-Yang
Format: Article
Language:English
Published: BMC 2010-04-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/77

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http://www.molecular-cancer.com/content/9/1/77

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