Expression of HIF-1α and VEGF in feline mammary gland carcinomas: association with pathological characteristics and clinical outcomes

Expression of HIF-1α and VEGF in feline mammary gland carcinomas: association with pathological characteristics and clinical outcomes

Abstract Background The microenvironment within solid malignant tumors, including feline mammary gland carcinomas (FMGCs), is commonly hypoxic, possibly due to the lack of functional blood vessels in rapidly proliferating neoplastic tissue. Malignant cells can undergo genetic and adaptive changes th...

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Bibliographic Details
Main Authors: Bo Chen, Susanne Je-Han Lin, Wen-Ta Li, Hui-Wen Chang, Victor Fei Pang, Pei-Yi Chu, Chin-Cheng Lee, Hiroyuki Nakayama, Ching-Ho Wu, Chian-Ren Jeng
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Veterinary Research
Subjects:
Feline
Mammary gland carcinoma
Hypoxia-inducible factor 1 alpha (HIF-1α)
Vascular endothelial growth factor (VEGF)
Online Access:http://link.springer.com/article/10.1186/s12917-020-02338-y

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http://link.springer.com/article/10.1186/s12917-020-02338-y

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