Replication and Oncolytic Activity of an Avian Orthoreovirus in Human Hepatocellular Carcinoma Cells

Replication and Oncolytic Activity of an Avian Orthoreovirus in Human Hepatocellular Carcinoma Cells

Oncolytic viruses are cancer therapeutics with promising outcomes in pre-clinical and clinical settings. Animal viruses have the possibility to avoid pre-existing immunity in humans, while being safe and immunostimulatory. We isolated an avian orthoreovirus (ARV-PB1), and tested it against a panel o...

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Bibliographic Details
Main Authors: Robert A. Kozak, Larissa Hattin, Mia J. Biondi, Juan C. Corredor, Scott Walsh, Max Xue-Zhong, Justin Manuel, Ian D. McGilvray, Jason Morgenstern, Evan Lusty, Vera Cherepanov, Betty-Anne McBey, David Leishman, Jordan J. Feld, Byram Bridle, Éva Nagy
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:Viruses
Subjects:
avian orthoreovirus
hepatocellular carcinoma
hepatitis C virus
oncolytic virus
syncytia
Online Access:http://www.mdpi.com/1999-4915/9/4/90

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http://www.mdpi.com/1999-4915/9/4/90

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