Toxin-Activating Stapled Peptides Discovered by Structural Analysis Were Identified as New Therapeutic Candidates that Trigger Antibacterial Activity against <i>Mycobacterium tuberculosis </i>in the <i>Mycobacterium smegmatis</i> Model

Toxin-Activating Stapled Peptides Discovered by Structural Analysis Were Identified as New Therapeutic Candidates that Trigger Antibacterial Activity against <i>Mycobacterium tuberculosis </i>in the <i>Mycobacterium smegmatis</i> Model

The structure-function relationships of toxin-antitoxin (TA) systems from <i>Mycobacterium tuberculosis</i> have prompted the development of novel and effective antimicrobial agents that selectively target this organism. The artificial activation of toxins by peptide inhibitors can lead...

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Bibliographic Details
Main Authors: Sung-Min Kang, Heejo Moon, Sang-Woo Han, Byeong Wook Kim, Do-Hee Kim, Byeong Moon Kim, Bong-Jin Lee
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Microorganisms
Subjects:
toxin-antitoxin system
structure-based drug discovery
antimicrobial candidate
stapled peptide
Online Access:https://www.mdpi.com/2076-2607/9/3/568

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https://www.mdpi.com/2076-2607/9/3/568

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