GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.

GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.

Expression of insulin in terminally differentiated non-beta cell types in the pancreas could be important to treating type-1 diabetes. Previous findings led us to hypothesize involvement of kinase inhibition in induction of insulin expression in pancreatic alpha cells.Alpha (αTC1.6) cells and human...

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Bibliographic Details
Main Authors: Dina Fomina-Yadlin, Stefan Kubicek, Amedeo Vetere, Kai Hui Hu He, Stuart L Schreiber, Bridget K Wagner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3252286?pdf=render

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http://europepmc.org/articles/PMC3252286?pdf=render

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