Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Abstract Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing. Epigenetic dynamics and immunometabolic reprogramming link to the...

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Bibliographic Details
Main Authors: Xudong Zhu, Zhiyang Chen, Weiyan Shen, Gang Huang, John M. Sedivy, Hu Wang, Zhenyu Ju
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00646-9