Potential Chronotherapeutic Optimization of Antimalarials in Systemic Lupus Erythematosus: Is Toll-Like Receptor 9 Expression Dependent on the Circadian Cycle in Humans?

Potential Chronotherapeutic Optimization of Antimalarials in Systemic Lupus Erythematosus: Is Toll-Like Receptor 9 Expression Dependent on the Circadian Cycle in Humans?

Toll-like receptor 9 (TLR9) belongs to the group of endosomal receptors of the innate immune system with the ability to recognize hypomethylated CpG sequences from DNA. There is scarce information about TLR9 expression and its association with the circadian cycle (CC). Different patterns of TLR9 exp...

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Bibliographic Details
Main Authors: Erika Aurora Martínez-García, Maria Guadalupe Zavala-Cerna, Andrea Verónica Lujano-Benítez, Pedro Ernesto Sánchez-Hernández, Beatriz Teresita Martín-Márquez, Flavio Sandoval-García, Mónica Vázquez-Del Mercado
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
toll-like receptor 9
systemic lupus erythematosus
circadian cycle
chronotherapy
chloroquine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01497/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01497/full

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