SHANK3 Co-ordinately Regulates Autophagy and Apoptosis in Myocardial Infarction

SHANK3 Co-ordinately Regulates Autophagy and Apoptosis in Myocardial Infarction

Cardiac remodeling and dysfunction are responsible for the high mortality after myocardial infarction (MI). We assessed the potential for Shank3 to alleviate the post-infarction cardiac dysfunction. The experimental MI mice model was constructed by left anterior descending coronary artery ligation....

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Bibliographic Details
Main Authors: Wanrong Man, Jing Gu, Bo Wang, Mingming Zhang, Jianqiang Hu, Jie Lin, Dong Sun, Zhenyu Xiong, Xiaoming Gu, Kaikai Hao, Baolin Guo, Gaoli Wei, Liang Zhang, Rui Song, Congye Li, Haichang Wang, Dongdong Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Physiology
Subjects:
SH3 and multiple ankyrin repeat domains 3
myocardial infarction
autophagy
apoptosis
cardiomyocytes
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.01082/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.01082/full

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