Improving production of Streptomyces griseus trypsin for enzymatic processing of insulin precursor

Improving production of Streptomyces griseus trypsin for enzymatic processing of insulin precursor

Abstract Background Trypsin has many applications in food and pharmaceutical manufacturing. Although commercial trypsin is usually extracted from porcine pancreas, this source carries the risks of infectivity and immunogenicity. Microbial Streptomyces griseus trypsin (SGT) is a prime alternative bec...

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Bibliographic Details
Main Authors: Yunfeng Zhang, Qixing Liang, Chuanzhi Zhang, Juan Zhang, Guocheng Du, Zhen Kang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Microbial Cell Factories
Subjects:
Streptomyces griseus trypsin
Autolysis
Unfolded protein response (UPR)
Pichia pastoris
Insulin
Online Access:http://link.springer.com/article/10.1186/s12934-020-01338-9

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http://link.springer.com/article/10.1186/s12934-020-01338-9

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