Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-κB, mTOR, Wnt Signalling Pathways

Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-κB, mTOR, Wnt Signalling Pathways

Neuropathy is a complication that affects more than 50% of long-standing diabetic patients. One of the causes of diabetes neuropathy (DN) is the apoptosis of Schwann cells due to prolonged exposure to high glucose and build-up of oxidative stress. Melatonin is a hormone that has a known antioxidant...

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Bibliographic Details
Main Authors: Yee Lian Tiong, Khuen Yen Ng, Rhun Yian Koh, Gnanajothy Ponnudurai, Soi Moi Chye
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Antioxidants
Subjects:
melatonin
apoptosis
reactive oxygen species
mitochondrial
Bcl-2
NF-κB
mTOR
Wnt
Online Access:https://www.mdpi.com/2076-3921/8/7/198

Internet

https://www.mdpi.com/2076-3921/8/7/198

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