Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection.

Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection.

Recombination activating gene (RAG)-deficient TCR (T Cell Receptor) Tg (transgenic) mice are routinely used as sources of monoclonal T cells. We found that after the transfer of T cells from a RAG-2-deficient 5CC7 TCR Tg mice into allogeneic hosts we recovered a population of T cells expressing dive...

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Bibliographic Details
Main Authors: Caroline Montaudouin, Laurent Boucontet, Marie-Pierre Mailhé-Lembezat, Maria-Encarnita Mariotti-Ferrandiz, Anne Louise, Adrien Six, Antonio A Freitas, Sylvie Garcia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2861594?pdf=render

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http://europepmc.org/articles/PMC2861594?pdf=render

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