Cardiovascular Insufficiency, Abdominal Sepsis, and Patients’ Age Are Associated with Decreased Paraoxonase-1 (PON1) Activity in Critically Ill Patients with Multiple Organ Dysfunction Syndrome (MODS)

Oxidative stress and uncontrolled inflammation are hallmarks of sepsis, leading to organ failure and death. As demonstrated in animal studies, oxidative stress can be alleviated by antioxidant therapies. Paraoxonase-1 (PON1) is a serum-based antioxidant, anti-inflammatory agent, detoxifier, and quor...

Full description

Bibliographic Details
Main Authors: Iwona Bednarz-Misa, Magdalena Mierzchala-Pasierb, Patrycja Lesnik, Sylwia Placzkowska, Krzysztof Kedzior, Andrzej Gamian, Malgorzata Krzystek-Korpacka
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2019/1314623