CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

Porcine reproductive and respiratory syndrome virus (PRRSV) and transmissible gastroenteritis virus (TGEV) are two highly infectious and lethal viruses causing major economic losses to pig production. Here, we report generation of double-gene-knockout (DKO) pigs harboring edited knockout alleles for...

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Bibliographic Details
Main Authors: Kui Xu, Yanrong Zhou, Yulian Mu, Zhiguo Liu, Shaohua Hou, Yujian Xiong, Liurong Fang, Changli Ge, Yinghui Wei, Xiuling Zhang, Changjiang Xu, Jingjing Che, Ziyao Fan, Guangming Xiang, Jiankang Guo, Haitao Shang, Hua Li, Shaobo Xiao, Julang Li, Kui Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
CRISPR/Cas9
PRRSV
TGEV
PDCoV
pig
Online Access:https://elifesciences.org/articles/57132

Internet

https://elifesciences.org/articles/57132

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