Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Abstract Background The Ras pathway genes KRAS, BRAF, or ERBBs have somatic mutations in ~ 60% of human colorectal carcinomas. At present, it is unknown whether the remaining cases lack mutations activating the Ras pathway or whether they have acquired mutations in genes hitherto unknown to belong t...

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Bibliographic Details
Main Authors: Snehangshu Kundu, Muhammad Akhtar Ali, Niklas Handin, Narendra Padhan, Jimmy Larsson, Maria Karoutsou, Kenneth Ban, Jacek R. Wiśniewski, Per Artursson, Liqun He, Mats Hellström, Tobias Sjöblom
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Genome Medicine
Subjects:
Forward genetics
piggyBac transposon
Colorectal cancer
Ras pathway
Online Access:http://link.springer.com/article/10.1186/s13073-017-0511-4

Internet

http://link.springer.com/article/10.1186/s13073-017-0511-4

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