Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice

Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by high levels of pathogenic autoantibodies and tissue damage. Multiple studies showed that dendritic cell (DC) activation plays a critical role in SLE pathogenesis. Human alpha 1 antitrypsin (hAAT) is a serine pr...

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Bibliographic Details
Main Authors: Ahmed Samir Elshikha, Ye Yuan, Yuanqing Lu, Mong-Jen Chen, Georges Abboud, Mohammad Ahsanul Akbar, Henrike Plate, Hedwig Wolney, Tanja Hoffmann, Eleni Tagari, Leilani Zeumer, Laurence Morel, Sihong Song
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050118301037

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http://www.sciencedirect.com/science/article/pii/S2329050118301037

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