A Truncated Form of IKKα Is Responsible for Specific Nuclear IKK Activity in Colorectal Cancer

A Truncated Form of IKKα Is Responsible for Specific Nuclear IKK Activity in Colorectal Cancer

Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and IKKα activity remains poorly understood. We have now analyzed 288 human colorectal cancer samples...

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Bibliographic Details
Main Authors: Pol Margalef, Vanessa Fernández-Majada, Alberto Villanueva, Ricard Garcia-Carbonell, Mar Iglesias, Laura López, María Martínez-Iniesta, Jordi Villà-Freixa, Mari Carmen Mulero, Montserrat Andreu, Ferran Torres, Marty W. Mayo, Anna Bigas, Lluis Espinosa
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712002689

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http://www.sciencedirect.com/science/article/pii/S2211124712002689

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