Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria

Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria

Vaccines that target Plasmodium falciparum gametocytes have the potential to reduce malaria transmission and are thus attractive targets for malaria control. However, very little is known about human immune responses to gametocytes present in human hosts. We evaluated naturally-acquired antibodies t...

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Bibliographic Details
Main Authors: Jo-Anne Chan, Damien R. Drew, Linda Reiling, Ashley Lisboa-Pinto, Bismarck Dinko, Colin J. Sutherland, Arlene E. Dent, Kiprotich Chelimo, James W. Kazura, Michelle J. Boyle, James G. Beeson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
gametocytes
PfEMP1
antibodies
malaria
P. falciparum
immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03126/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03126/full

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