Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABA(A) receptor α4 subunit

Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABA(A) receptor α4 subunit

Despite numerous advances, treatment-resistant seizures remain an important problem. Loss of neuronal inhibition is present in a variety of epilepsy models and is suggested as a mechanism for increased excitability, leading to the proposal that grafting inhibitory interneurons into seizure foci migh...

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Bibliographic Details
Main Authors: Manoj K. Jaiswal, Sotirios A Keros, Mingrui A Zhao, Melis eInan, Theodore H Schwartz, Stewart A Anderson, Gregg E Homanics, Peter A. Goldstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Epilepsy
interneuron
Cortex
extrasynaptic
GABAA receptor
α4 subunit
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00127/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00127/full

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