Calcium-Sensing Receptor Mediates β-Amyloid-Induced Synaptic Formation Impairment and Cognitive Deficits via Regulation of Cytosolic Phospholipase A2/Prostaglandin E2 Metabolic Pathway

Calcium-Sensing Receptor Mediates β-Amyloid-Induced Synaptic Formation Impairment and Cognitive Deficits via Regulation of Cytosolic Phospholipase A2/Prostaglandin E2 Metabolic Pathway

Calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCRs). Soluble β-amyloid peptide (Aβ) is one of the orthosteric modulators of CaSR, while, the role and underlying mechanism of CaSR in cognitive decline in Alzheimer’s disease (AD) is unclear. In this study, molecular technology such...

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Bibliographic Details
Main Authors: Chenxi Feng, Xiaoming Bao, Ling Shan, Yunxiang Ling, Yanfei Ding, Jia Wang, Yanzi Cao, Qinwen Wang, Wei Cui, Shujun Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease (AD)
β-amyloid peptide (Aβ)
calcium-sensing receptor (CaSR)
synapse formation
cytosolic phospholipase A2
prostaglandin E2
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00144/full

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https://www.frontiersin.org/article/10.3389/fnagi.2020.00144/full

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