Metabolism of the unnatural anticancer lipid safingol, l-threo-dihydrosphingosine, in cultured cells

Metabolism of the unnatural anticancer lipid safingol, l-threo-dihydrosphingosine, in cultured cells

We studied the metabolism of radioactively labeled safingol (l-threo-dihydrosphingosine) in primary cultured neurons, B104 neuroblastoma cells, and Swiss 3T3 fibroblasts, and compared it to that of its natural stereoisomer d-erythro-dihydrosphingosine. Both sphingoid bases are used as biosynthetic p...

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Bibliographic Details
Main Authors: Mihaela Dragusin, Cristian Gurgui, Günter Schwarzmann, Joerg Hoernschemeyer, Gerhild van Echten-Deckert
Format: Article
Language:English
Published: Elsevier 2003-09-01
Series:Journal of Lipid Research
Subjects:
primary cultured neurons
neuroblastoma cells B104
Swiss 3T3 cells
l-threo-sphinganine
ceramide
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520337421

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http://www.sciencedirect.com/science/article/pii/S0022227520337421

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