Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria.

Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria.

We have established a novel in vitro co-culture system of human brain endothelial cells (HBEC), Plasmodium falciparum parasitised red blood cells (iRBC) and peripheral blood mononuclear cells (PBMC), in order to simulate the chief pathophysiological lesion in cerebral malaria (CM). This approach has...

Full description

Bibliographic Details
Main Authors: Loke Tim Khaw, Helen J Ball, Jacob Golenser, Valery Combes, Georges E Grau, Julie Wheway, Andrew J Mitchell, Nicholas H Hunt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3709908?pdf=render

Internet

http://europepmc.org/articles/PMC3709908?pdf=render

Similar Items