Treatment-Resistant Major Depression:Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy

Treatment-Resistant Major Depression:Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy

Major depressive disorder (MDD) remains a huge personal and societal encumbrance. Particularly burdensome is a virulent subtype of MDD, treatment resistant major depression (TMRD), which afflicts 15-30% of MDD patients. There has been recent interest in N-methyl-D-aspartate (receptors (NMDARs) as t...

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Bibliographic Details
Main Authors: Charles eZorumski, Peter eNagele, Stephen James Mennerick, Charles eConway
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Psychiatry
Subjects:
Hippocampus
Ketamine
Suicide
antidepressant
metaplasticity
NMDA receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00172/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00172/full

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