Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes

Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes

Hepatitis B virus<b> (</b>HBV) chronic infection is a critical risk factor for hepatocellular carcinoma. The innate immune response to HBV infection is a matter of debate. In particular, viral escape mechanisms are poorly understood. Our study reveals that HBV RNAs are not immunostimulat...

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Bibliographic Details
Main Authors: Lise Lauterbach-Rivière, Maïwenn Bergez, Saskia Mönch, Bingqian Qu, Maximilian Riess, Florian W. R. Vondran, Juliane Liese, Veit Hornung, Stephan Urban and Renate König
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Viruses
Subjects:
hepatitis B virus <b>(</b>HBV)
innate immunity
STING
cGAS
innate immune sensing
interferon response
Online Access:https://www.mdpi.com/1999-4915/12/6/592

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https://www.mdpi.com/1999-4915/12/6/592

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