Combined effect of 17β-estradiol and resveratrol against apoptosis induced by interleukin-1β in rat nucleus pulposus cells via PI3K/Akt/caspase-3 pathway

Combined effect of 17β-estradiol and resveratrol against apoptosis induced by interleukin-1β in rat nucleus pulposus cells via PI3K/Akt/caspase-3 pathway

Background: In previous studies, both 17β-estradiol (E2) and resveratrol (RES) were reported to protect intervertebral disc cells against aberrant apoptosis. Given that E2 has a better anti-apoptotic effect with more cancer risk and RES has an anti-apoptotic effect with less cancer risk, the combine...

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Bibliographic Details
Main Authors: Si-Dong Yang, Lei Ma, Da-Long Yang, Wen-Yuan Ding
Format: Article
Language:English
Published: PeerJ Inc. 2016-01-01
Series:PeerJ
Subjects:
Apoptosis
Resveratrol
PI3K/Akt
Intervertebral disc degeneration
Nucleus pulposus
17β-estradiol
Online Access:https://peerj.com/articles/1640.pdf

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