iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications

The Cre-Lox system allows high spatiotemporal control of genetic modifications. Here the authors present iSuRe-Cre that significantly increases Cre activity in reporter expressing cells, which ultimately increases the efficiency and reliability of Cre-dependent reporter and gene function analysis.

Bibliographic Details
Main Authors: Macarena Fernández-Chacón, Verónica Casquero-García, Wen Luo, Federica Francesca Lunella, Susana Ferreira Rocha, Sergio Del Olmo-Cabrera, Rui Benedito
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10239-4