Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126

Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126

Heat shock protein A12B (HSPA12B) is predominately expressed in endothelial cells (ECs) and has been reported to protect against cardiac dysfunction from endotoxemia or myocardial infarction. This study investigated the mechanisms by which endothelial HSPA12B protects polymicrobial sepsis–induced ca...

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Bibliographic Details
Main Authors: Xia Zhang, Xiaohui Wang, Min Fan, Fei Tu, Kun Yang, Tuanzhu Ha, Li Liu, John Kalbfleisch, David Williams, Chuanfu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
endothelial HSPA12B
polymicrobial sepsis
cardiomyopathy
exosomes
microRNAs
endothelial adhesion molecules
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00566/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00566/full

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