The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8+ T Cells During an Acute Retroviral Infection

The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8+ T Cells During an Acute Retroviral Infection

Cytotoxic CD8+ T lymphocytes (CTL) efficiently control acute virus infections but can become exhausted when a chronic infection develops. The checkpoint receptor PD-1 suppresses the functionality of virus-specific CD8+ T cells during chronic infection. However, the role of the PD-L1/PD-1 pathway dur...

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Bibliographic Details
Main Authors: Paul David, Dominik A. Megger, Tamara Kaiser, Tanja Werner, Jia Liu, Lieping Chen, Barbara Sitek, Ulf Dittmer, Gennadiy Zelinskyy
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
CD8 T cells
PD-1
PD-L1
retrovirus
caspase 3
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00054/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00054/full

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