Diuretic Activity of a Novel Peripherally-Restricted Orally-Active Kappa Opioid Receptor Agonist

<i>Kappa</i>-opioid agonists (KOAs) enhance cardiac performance, as well as reduce infarct size and prevent deleterious cardiac remodeling following myocardial infarction. Additionally, KOAs promote diuresis; however, there has been limited development of KOAs as a class due to the promo...

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Bibliographic Details
Main Authors: Tyler C. Beck, Matthew A. Hapstack, Gautam S. Ghatnekar, Thomas A. Dix
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Medical Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3271/7/9/93