Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies

Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies

Areas of HIV envelope (Env) that aren’t covered by glycans are potential targets for antibodies. Here, the authors computationally design small protein mimics of four such epitopes and show that they can induce Env binding antibodies in rabbits.

Bibliographic Details
Main Authors: Cheng Zhu, Elena Dukhovlinova, Olivia Council, Lihua Ping, Edgar M. Faison, Shamit S. Prabhu, E. Lake Potter, Stephen L. Upton, Guowei Yin, James M. Fay, Laura P. Kincer, Ean Spielvogel, Sharon L. Campbell, S. Rahima Benhabbour, Hengming Ke, Ronald Swanstrom, Nikolay V. Dokholyan
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08876-w

Internet

https://doi.org/10.1038/s41467-019-08876-w

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